The Big Reds were cold from the floor in the first half and only led 21-18 at halftime. But a 16-9 third quarter edge put them in control of the contest.
Muskegon improved to 9-2 overall and 4-1 in conference play.
Mardrekia Cook had another huge night for Muskegon with 23 points and 20 rebounds. Tierra Williams added nine points for the winners.
Sophie Riemersma had 11 points for Zeeland East.