The Big Reds improve to 15-3 overall this season and remain unbeaten in the O-K Black Conference at 9-0.
The Big Reds jumped out to a 12-4 lead after the first quarter, 24-17 at halftime and 36-26 after three quarters.
Michael Littlejohn paced Muskegon with 22 points, while Jermane Golidy added 10 and Deandre Carter chipped in with eight points.
Linwood Lee contributed with five rebounds and six assists.
The Knights were led by Zach Kregel with nine points.