The set scores were 25-12, 25-11 and 25-18.
With the victory, the Jayhawks improve to 26-10 overall and 13-2 in conference play.
Ashly Schuitema led Muskegon with 10 kills, six digs, and four aces while Lindsey Jacobs had 32 assists.
Rachel Brown added 11 kills for the Jayhawks while Alysia Folkersma had eight blocks.
MCC will go on the road to play Ancilla College on Thursday.