The Big Reds are now 7-0 overall and 3-0 in the league.
Sam Cornett and Markell Jackson led the way for the Big Reds. Cornett poured in 21 points while Jackson posted a double-double with 17 points and 11 rebounds.
Muskegon trailed 7-4 after one quarter of play, then outscored the Knights by 10 in the second quarter to take a 21-14 halftime lead.
Kenowa Hills rallied and cut its deficit to two points by the end of the third quarter, but the Big Reds sealed the game in the fourth with a 25-12 advantage.
Muskegon had 23 steals.