The Tigers jumped out to a 19-12 first-quarter lead and led 28-22 at half time.
Muskegon Catholic kept the Tigers in check to start the second half, trailing 38-34 after the third quarter.
Kevon Washington paced the Tigers with 16 points while Arlester Sims finished with 15.
Jared Dugener led MCC (7-5, 2-4) with 23 points, seven rebounds and three blocks. Andre Watson added 10 points, five rebounds and four assists with Seth Arends adding five points.