After the first quarter, Muskegon led 18-11 before extending the lead to 35-22 at halftime.
In the third quarter, the Jayhawks outscored Kalamazoo Valley 21-14 to take a 56-36 lead.
Yasmine Colon paced Muskegon with 21 points while Iyana Brown added 16 points and 13 rebounds. Julia Tierman added 11 points.
Muskegon is now 14-3 overall and 6-2 in conference play.