The Panthers trailed 20-18 entering the fourth quarter, but miscues and turnovers swung the game away to the hosts.
Brandon Quinn led Hesperia’s offense with 160 yards rushing on 24 carries, including a touchdown run. Amando Escobejo and Hunter Billman both had TD runs for the Panthers.
Sam Koch led the Hesperia defense with eight tackles.
The Panthers look to rebound in Week 3 when they host White Cloud on Friday, September 10 at 7 p.m.