The Big Reds were outscored, 19-12 in the first quarter. Kalamazoo Central had a 13-10 advantage in the second period and led, 32-22 at the half.
Muskegon bounced back in the third quarter, outscoring Kalamazoo, 12-7 to shave its deficit to 39-34 going into the fourth quarter. Each team scored 12 points in the final eight minutes.
Terrance Davis scored 17 points to lead the Big Reds, while Anthony Sydnor III added 10 and Stanley Cunningham contributed seven.
Kalamazoo Central was led by Hutch Ward with 15 points and Scott Hughes added 13.