The Turtles dropped a 106.5-78.5 to the Maroons, ranked No. 3 in Division 3.
Despite facing illness, injury and fatigue, the Turtles swam to 22 personal bests.
The team of Delaney Buckner, Naomi Huttenga, Robyn Hunt and Sydney Sytsema led the way with first-place finishes in the 200 medley relay (1:59.97) and 200 free relay (1:49.57).
Buckner also posted first-place wins in the 200IM (2:18.15) and 100 fly (1:02.59).
Hunt posted a season-best time of 5:44.54 with a victory in the 500 free.
The Turtles (4-3, 2-2) travel to Ludington on Thursday.