The Sailors fell to the Hawkeyes, 100-69.
The 200 medley relay team of Kelby Miller, Santiago Sanchez, Diego Hubby and Quinn McKenna earned a second-place finish with a time of 1:53.5.
McKenna and Miller also earned second-place spots in the 50 free (24.06) and 100 fly (1:06.52), respectively.
Jack Walkenhurst swam to a third-place finish in the 200 free with a time of 2:16.71.
Mona Shores will be back in the pool Monday as they host Holland.