Calvary led 8-3 after one quarter and 35-3 at the half. The lead was 50-18 after three quarters.
McKena Wilson led the Eagles with 37 points, 10 rebounds and three steals. Her eight 3-pointers tied the school record of Kelsey Richards.
Nora Pollock added seven points, eight rebounds, 12 steals and four assists.
Saabiria Addullah led Wellspring with 15 points, all on 3-pointers.
Calvary (8-9, 3-1) plays at Grand River Prep on Tuesday.