Ludington (3-5) opened the scoring with a one yard run from quarterback Jared Collins in the first quarter to take a 7-0 lead.
Lakeview tied the game 7-7 with a touchdown three minutes into the second quarter.
The Orioles responded 18 seconds later on a 63-yard touchdown run from Andrew Jones to give Ludington a 13-7 lead.
Lakeview then took a 14-13 lead with just under four minutes to play in the first half.
Ludington regained its lead with a 21-yard rushing touchdown from Collins with only 10 seconds remaining in the first half.
The Orioles converted on a two-point conversion on a pass from Collins to Erick Quick to give Ludington a 21-14 halftime lead.
The second half was scoreless.
Ludington will finish out its season next week hosting Mason County Central.