The Panthers are 8-0 on their season.
Garrit Yates led the Panthers with 224 yards on 11 carries and two touchdowns, while Mark Workman added 216 yards on 10 carries and three touchdowns.
Panther quarterback Brendan Mcaree completed two passes for 78 yards and two touchdowns while also rushing for a touchdown from 16 yards out.
Brandon Goins also scored a touchdown for the Panthers while finishing with 44 yards on eight carries.
Davian Gowens and Mcaree each had one interceptions for the Panthers, while Kanin Witte recovered a fumble for Hesperia.
Hesperia will closed out its season against North Muskegon looking for a perfect record.