Hesperia, facing a 28-0 deficit in the third quarter, got its lone touchdown when Mark Workman scored on a one-yard plunge.
Saugatuck went on to score 14 unanswered points to finish out the game.
Saugatuck quarterback Blake Dunn completed 12 of 18 passes for 153 yards and three touchdowns. He also rushed for 195 yards and three touchdowns on 36 carries.
The Panthers were led by Workman, who rushed for 79 yards and a touchdown on 16 carries.