Pitcher Cam Miller, from Central Michigan University, earned the victory on the mound by tossing six innings and only allowing two runs.
Andrew Null got the save, pitching three innings of scoreless relief and striking out six batters.
Muskegon grabbed a 2-0 lead in the first inning on back-to-back RBI hits by Ryan Blake-Jones and Cameron Bair.
Blake-Jones, who had three hits on the night, clubbed his third home run of the season in the fifth to put the Clippers up 3-0.
The Green Giants pushed across two runs in the sixth, then the Clippers answered in the seventh with an RBI single by Jacob Buchberger.
Muskegon’s Bryce Kelley ended the scoring with a solo home run in the eighth inning.
Bair led the offense with four hits, while Connor Henderson and Wyatt Featherston added two apiece.
The Clippers are now 2-1 on the season and tied for first place atop the Great Lakes Summer Collegiate Baseball League’s Northern Division.
Game 2 of the series will be Friday at 7:05 p.m.