Rachel Romero led the Panthers with seven kills on the night while Emily Bayle totaled eight digs, six kills and eight aces.
Aria Thomas led Hesperia with 12 assists.
Layna Cartwright led the Red Devils with five kills while Abbie Fowler totaled eight assists.
Kennedy Greene and Gianna Reed each had seven digs for Holton.
Hesperia is now 2-1 in conference play and 5-5 overall on the season.