Fowler connected with four different receivers for scores and threw just six incompletions in a 44-28 over Lakeview.
Bret Hosmer led Holton with 90 yards and a touchdown on five receptions while Kevin Erickson had seven receptions for 58 yards and a touchdown for Holton (3-2, 2-1 CSAA Silver).
Cameron Edgerton caught two touchdown passes while Rice Robins found the end zone as well. Erickson led Holton with 54 yards on six carries.
Dylan Cartwright was the leading tackler for the Red Devils with eight tackles. Robins and Aaron Waterman chipped in with seven tackles of their own.
The Red Devils will host Kent City next Friday.