The Lumberjacks allowed seven unanswered goals to erase an early slim one-goal lead before falling to the Dubuque Fighting Saints by an 8-3 margin.
Muskegon, which is 1-1 on the season, will return home for its home opener on Friday against Team USA Under-18 squad at a special 10:30 a.m. faceoff.
The Jacks opened the scoring as captain Cody Croal notched his first of the season 1:21 into the contest to give Muskegon a 1-0 lead.
Dubuque responded 4:07 into the first period with a power-play tally from Erik Pahlsson.
Justin Solovey gave the Jacks a 2-1 lead 12:18 into the first period before the Fighting Saints went on a seven straight goal barrage.
Josh Giuliani (14:41) and Colin Frank (18:38) each scored to give Dubuque a 3-2 lead heading into the first intermission.
The Fighting Saints outscored Muskegon by a 4-0 margin during the second period to take a 7-2 advantage heading into the third. Gavin Cornforth (2:53), Juraj Pekarcik (9:07), Jake Sondreal (9:20) and Michael Barron (15:01) each found the back of the net for Dubuque.
Dubuque added their seventh straight goal at the 5:21 mark of the third period as James Reeder gave the Fighting Saints an 8-2 lead.
David Klee closed out the game scoring with a goal 13:53 into the third period for the Lumberjacks.
The Fighting Saints outshot Muskegon by a 33-23 margin.
Muskegon was 1-for-6 on the power play while killing off two of Dubuque’s four extra-man advantages.
Lucas Szyszka suffered the loss in net for Muskegon, stopping 14-of-19 shots faced, while Paxton Geisel made 11 saves on 14 shots in relief for the Jacks from between the pipes.